Parathyroid hormone: A Laboratory Test not Just for Endocrinologists
نویسندگان
چکیده
منابع مشابه
Parathyroid hormone without parathyroid glands.
In mammals, PTH is a component in a complex signaling system involving three structurally related ligands and two G protein-coupled receptors, which share significant amino acid sequence homology (Fig. 1). PTH is a peptide hormone comprising 84 amino acids that is made by the parathyroid glands (and to a much smaller extend by the thymus) and acts through the PTH/PTH-related peptide (PTHrP) rec...
متن کاملPurification and characterization of a receptor for human parathyroid hormone and parathyroid hormone-related peptide.
The human parathyroid hormone (PTH) receptor (hPTH1R), containing a 9-amino acid sequence of rhodopsin at its C terminus, was transiently expressed in COS-7 cells and solubilized with 0.25% n-dodecyl maltoside. Approximately 18 microg of hPTH1R were purified to homogeneity per mg of crude membranes by single-step affinity chromatography using 1D4, a monoclonal antibody to a rhodopsin epitope. T...
متن کاملParathyroid hormone, a uremic toxin.
Despite the innovations in the treatment of secondary hyperparathyroidism, there are uremic patients with marked elevation in PTH levels. Uremic toxicity is in part attributable to the excess of circulating PTH. It has been known for many years that PTH may induce changes in cell calcium, a key intracellular signal required for normal cell function. The effect of PTH in dialysis patients is not...
متن کاملPTHLH (parathyroid hormone-like hormone)
DNA/RNA Description PTHLP is encoded by a single gene that is highly conserved among species. The gene is composed of 7 exons spanning a region of 13,899 bases (Start: 28,002,284 bp from pter; End: 28,016,183 bp from pter). Orientation: minus strand. The genomic DNA for the PTHLP gene was isolated from a human placental genomic library. Transcription The sequence is supported by 3 sequences fro...
متن کاملA Test for Abnormally Large Amounts of Parathyroid Hormone in the Blood.
In a previous communication (1) we have described a test for the determination of small amounts of parathyroid hormone. The test is based on the fact that if a soluble calcium salt is given to rabbits by stomach tube in repeated doses, the serum calcium will rise after the first dose while subsequent administrations will have less and less effect. If, however, parathyroid hormone is injected at...
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ژورنال
عنوان ژورنال: The International Journal of Artificial Organs
سال: 1981
ISSN: 0391-3988,1724-6040
DOI: 10.1177/039139888100400301